LOSH collaborates with workers, unions, community organizations, employers, academics, students, governmental representatives, and health professionals to improve health and safety conditions for workers in Southern California. Initiatives include health and safety training, education for low-income, minority, and immigrant workers, public advocacy, and participation in industry-wide research relating to policy issues in California.

LOSH is a subunit of UCLA's Institute for Research on Labor and Employment (IRLE) and the Center for Occupational and Environmental Health (COEH)